Khenpo Tashi Sangpo Amipa was born in 1973 in Sakya, Tibet, where he received his first training and education.

At the age of 10, he entered the main Sakya Monastery, Thubten Lhakhang Chenmo, and took up the novice-monk ordination. He studied at the monastery until 1994, when he escaped from Tibet to India. He found refuge in Dehra Dun, home to the Sakya Monastery where His Holiness Sakya Trizin was also living in exile. He enrolled in the Sakya College, a Monastic University, where he studied and deepened his understanding of various aspects of the Buddhist practice and philosophy. He completed his studies in the year 2000 and was awarded ‘Kachu-pa’ and ‘Loppön’ degrees.
In May 2000, he moved to Switzerland to take care of the Thupten Changchup Ling centre in Arosio as resident monk. He has since been in charge of the temple leading daily rituals and meditation sessions.
In 2008, he returned to India to take Bikshu vows, i.e. the vows of a fully ordained monk.

In 2014, before his passing, Khenchen Sherab Gyaltsen Amipa chose Khenpo Tashi Sangpo as his heir and left him in charge of his European centres.

On 3 July 2016, His Holiness the Sakya Trizin conferred upon Lama Tashi Sangpo the titile of Khenpo (abbot) at the European centre Sakya Tsechen Ling in Kuttolsheim/Strassburg as a sign of appreciation for his committed guidance and support in taking care of the Sakya Centres which were founded by Khenchen Sherab Gyaltsen Amipa.